Important risk information Prescribing information

Relieve Your Osteoarthritis Knee Pain With Zilretta.

A single injection that can provide
major knee pain relief for about 3 months.

Call or text today to find a specialist in your area or request a dedicated ZILRETTA sales representative.

Call (888) 600-GETZ Text* "GETTHEZ" to 21000
Rod Woodson

Retired NFL Player Hall of Fame Member
ZILRETTA Patient
Mike Eruzione

1980 USA Olympic Hockey Team
ZILRETTA Patient

Meet ZILRETTA

Our Secret: Microspheres.

ZILRETTA is the first and only FDA-approved treatment for osteoarthritis knee pain that uses extended-release microsphere technology.

  • The microspheres stay put, slowly and continually releasing their medicine for about 3 months.
  • ZILRETTA microspheres stay in your knee joint—right where the pain is.
  • After releasing all their medicine into the knee joint, the microspheres break down and turn into carbon dioxide and water, which are naturally found in the body.

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What is ZILRETTA?
ZILRETTA is an extended-release corticosteroid approved to manage osteoarthritis knee pain. The benefits and risks of repeat injections have not been demonstrated.
Who should not receive ZILRETTA?
You should not receive a ZILRETTA injection if you are allergic to corticosteroids, triamcinolone acetonide, or any other component of the product.
Please see full Important Risk Information below.

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Featured ZILRETTA Patient Athletes

The thing I love about ZILRETTA is that it helped me live my life with less knee pain. I can be active, I can go hiking, and I can do the things I love with less knee pain.

Rod Woodson

Retired NFL Player Hall of Fame Member

ZILRETTA patient

One of the things you want to do as you get older is live a good life. And ZILRETTA has given me the opportunity to live a good life with less pain, plain & simple.

Mike Eruzione

1980 USA Olympic Hockey Team

ZILRETTA patient

The thing I love about ZILRETTA is that it helped me live my life with less knee pain. I can be active, I can go hiking, and I can do the things I love with less knee pain.

Rod Woodson

Retired NFL Player Hall of Fame Member

ZILRETTA patient

Read More

One of the things you want to do as you get older is live a good life. And ZILRETTA has given me the opportunity to live a good life with less pain, plain & simple.

Mike Eurzione

1980 USA Olympic Hockey Team

ZILRETTA patient

Read More

Getting Started
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Thank You!

We look forward to sharing helpful information about the Z for your knee and tips to help manage your osteoarthritis knee pain.

In the meantime, visit our "Find a Doctor" tool to find healthcare providers in your area who are using ZILRETTA to help their patients with osteoarthritis knee pain.

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Thank you for your interest in ZILRETTA!

Take the opportunity now to learn more about ZILRETTA by visiting our website and requesting a Dedicated Sales Representative.

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Indication and Important Risk Information

What is ZILRETTA?
ZILRETTA (triamcinolone acetonide extended-release injectable suspension) is an extended-release corticosteroid approved to manage osteoarthritis knee pain. The benefits and risks of repeat injections have not been demonstrated.
Who should not receive ZILRETTA?
You should not receive a ZILRETTA injection if you are allergic to corticosteroids, triamcinolone acetonide, or any other component of the product.
What possible side effects of corticosteroids could occur with ZILRETTA?
  • Rare serious allergic reactions
  • Effects in the injected knee such as infection (with pain, swelling and restricted motion) or joint damage
  • Increased chance of getting an infection, and a decreased ability to fight an infection
  • Effects on hormone production. These effects can be reversible
  • Elevated blood pressure, sodium and water retention, and potassium loss
  • Intestinal perforation if you have certain gastrointestinal disorders
  • Weakening of bones
  • Changes in behavior or mood disturbances
  • Increased pressure inside the eye
What are the most common side effects of receiving a ZILRETTA injection?
In multiple clinical trials, the most common side effects seen in people taking ZILRETTA were joint pain, headache, joint swelling, back pain, sore throat and runny nose, upper respiratory tract infection, and bruising.
What should you tell your doctor BEFORE receiving a ZILRETTA injection?
Tell your doctor about all of the medications you are taking (including both prescription and over-the-counter medicines) and about any medical conditions, especially if you have high blood pressure, heart disease, ulcers, diverticulitis or other gastrointestinal disorders, kidney problems, diabetes, glaucoma, behavior or mood disorders, and/or infections.
What should you tell your doctor AFTER receiving a ZILRETTA injection?
Contact your doctor if you develop a fever or other signs of infection, have an increase in pain along with swelling of the injected knee, restriction of joint motion, or a general feeling of discomfort. Contact your doctor immediately if you are exposed to chicken pox or measles, or for any new or worsening changes in behavior or mood.
These are not all of the possible side effects with ZILRETTA or corticosteroid medications. Please see the full Prescribing Information at www.ZILRETTALabel.com/PI.pdf. Always contact your doctor if you have questions or experience any side effects.
You are encouraged to report side effects to the FDA: Call 1-800-FDA-1088 (332-1088), or visit www.fda.gov/medwatch. You may also report side effects to Flexion at 1-844-FLEXION (353-9466).
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